482 The predictive and diagnostic biomarkers of immune-related adverse events vary by the affected organ

The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte (PLR), and eosinophil count have been used as biomarkers of immune-related adverse events (irAEs) associated with immune checkpoint inhibitor (ICI) treatment. As no report has yet compared by the affected organs, we explored this topic. A total 284 patients on ICIs included 102 irAEs 182 without. following comparisons were statistically significant (*p<0.05, **p<0.01, ***p<0.001). irAE group evidenced a higher body mass index (BMI) than non-irAE group***. Also, was at onset in Patients endocrine disorders older others**, more often female*, BMI* lymphocyte counts* lower NLR PLR did group*. More gastrointestinal female male* their platelet that In skin disorders, higher**, while C-reactive protein (CRP) level to respiratory BMI group*, monocyte counts CRP group**. conclusion, predictive and/or diagnostic for vary organ.